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MRSA & Joint Body Pains
Started by Ramona |
Posted: December 27, 2009 at 01:43 | |
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This forum site has given me great relief. I got MRSA two years ago. Boils formed on the back of my knee and I, thankfully, called my doctor's office. I haven't had any outbreaks for a while, but recently was suppose to go in for spinal surgery. I went to the hopsital for the pre-op and the surgeon called me a day or so later and asked me to come into his office. When I got there, he was very concerned and told me that my blood was infected with MRSA and that he could not go ahead with the surgery until it was cleared up. My family doctor had been treating me w/antibiotics when I first showed signs of MRSA, but the surgeon told me that if I took Zyvox, it would kill it. My family doc didn't put me on the Zyvox because I was on other meds that couldn't be taken w/Zyvox. Had to slowly go off all of my other meds over a three week period with some impressive withdrawal symptoms. Finally, just before I was going to begin the Zyvox, my husband had to take me to emergency and I had to have my appendix removed. I have been suffering extreme joint pain and flu like body ache. The itense pain has brought me to tears.Even tho I ws hurting, I took a slow walk up the street and just couldn't understand why I was having pain in my knees, hips and allover body flu ache pains. Once I read how a lot of other folks are dealing with the same thing, and that some of you are having the same issues, I just can't express how glad I was that someone else knew what I was talking about. Thanks to everyone for sharing. I'm going to try a lot of the suggestions I've read here and see what happens. I'll be going to have my blood tested once again, and I hope it's good news. I pray and hope we all have a Happy New Year! Ramona 15920
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Re: MRSA & Joint Body Pains
Reply #1 by Shelly B. |
Posted: December 28, 2009 at 14:39 | |
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When they removed your appendix... was there any mention of MRSA then? It's a bit scary that they did surgery (understood that it was an emergency and there was no way around it) while your blood was infected with MRSA. I would contact the hospital that performed your appendectomy (sp?) and ask them about blood test results regarding any infections... they may already have your answer for you as to if you are colonized or not. Best wishes in the New Year! 15926
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Re: MRSA & Joint Body Pains
Reply #2 by Sandi |
Posted: December 28, 2009 at 14:47 | |
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Watch Zyvox, I could not take it, I had severe stomach pains and had to stop and go to Vancomycin. Be careful I hope Zyvox works for you. I doubt that the other hospital will tell you because they will not want to take blame. Good Luck 15927
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Re: MRSA & Joint Body Pains
Reply #3 by postman |
Posted: December 28, 2009 at 15:26 | |
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Ramona states PRE-OP, blood bourne, previous boils, appendectomy. Maybe ladyK can explain my perplexion, boils2blood, where did the vanco go? 15929
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Re: MRSA & Joint Body Pains
Reply #4 by ladyk |
Posted: December 29, 2009 at 17:52 | |
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postman - Since we do not have access to case particulars such as previously attempted antibiotic therapy, possible VRSA… or choice may be as simple as surgeon’s drug preference, etc. one can only speculate as to why vancomycin was not attempted. I agree it is a more common approach to utilize vancomycin or combination vancomycin/rifampin therapy prior to linezolid (Zyvox), due to lower susceptibility averages/patient tolerance/extreme side effects. (All things considered - including leaning for various reasons… some studies will show zyvox having greater results vs vanco concerning such afflictions as MRSA pneumonia.) This is good example of why an ID specialist should be on board, and follow up including cultures of MRSA infected patients should be mandatory. If I was to speculate… (which I attempt to avoid) I’d say ‘surgeon’ was looking for quick kill rate due to potential seriousness of patient condition concerning mortality threat/appendix perforation/immediate corrective surgery. Often patient’s pre-existing medical maladies (including MRSA) are back burnered ‘due to lack of time afforded when dealing with life threatening prognosis’ where considerations are secondary to saving one’s life. (Of interest) Isolates were susceptible to vancomycin, 54/55 (98%) to linezolid, 80/95 (84%) to rifampin, and 69/85. (Journal of Clinical Microbiology & Infectious Diseases) ladyk In one retrospective analysis of a subgroup of patients in a prospective nosocomial pneumonia study, linezolid (zyvox) was associated with greater control rates than vancomycin. Whether this is applicable to pneumonia caused by CA-MRSA remains to be seen. Additionally you may find study below of interest… We report a 54-year-old male patient with an infection caused by linezolid-resistant methicillin-resistant Staphylococcus aureus (MRSA), isolated after long-term, repeated use of linezolid. *Five MRSA strains isolated from our patient were preserved and submitted to bacteriological analysis. All five of these strains were found to have identical genotypes by pulsed-field gel electrophoresis. Two strains isolated in the early hospital period were sensitive to linezolid, while three isolated in the late hospital period were resistant. These three strains that had acquired resistance to linezolid were found to have a G2576T point mutation in the 23SrRNA domain V. Linezolid-resistant MRSA is rare, but may occur with the long-term, repeated administration of linezolid. (Journal of Infection and Chemotherapy) Goes to the point and should slam home ‘judicious use of antibiotics’ when considering multi-drug resistant bacteria! 15941
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Re: MRSA & Joint Body Pains
Reply #5 by postman |
Posted: December 29, 2009 at 21:24 | |
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ladyK, I dont know which is scarier, you or MRSA. Not only do you bring back to me my theory MRSA is evolving, you lay it at my feet. One host 5 strains, 3 mutated. SuperBug is a poor moniker, more accurately doomsdayBUG with 50 years of practice. The leap can be made the genectic sequence has evolved and can cross genome boundaries a.k.a. gram negative and gram positive. This is the only explanation for the immergence of spore producing C.Diff. ladyK's sitation clears says, "isolated in the late hospital period", I can guarantee the surprize of the discovery of the "late". This is a foretelling if not a prophecy. Just to remind I cultured Zyvox only. The only thing that would save me from these three strains is the fact my immune system has never developed that particular antibody. No antibiotic will help, in fact only make it worse. 15947
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Re: MRSA & Joint Body Pains
Reply #6 by Nancy R |
Posted: December 29, 2009 at 23:51 | |
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In my own case, since I cannot under any circumstances take vancomycin, Zyvox had to be used to save my life. It didn't work ultimately, but it sure did initially. That is why having a GOOD ID is imperative. They have the latest information and can determine based on their data the best cocktails to deliver. Zyvox has its place in medicine, but it is very damaging as are most of the super antibiotics. When its a choice between dying within 48 hours, or taking Zyvox, you take the Zyvox and hang on for the ride. 15948
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Re: MRSA & Joint Body Pains
Reply #7 by postman |
Posted: December 30, 2009 at 05:31 | |
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The more I read this thread the more it BUGS me, forgive the pun. I have mentioned my second culture was negative for MRSA, positive for E.Coli. It was the lab for a surgery on an intestinal abcess, a fistula that remained internal and was draining in my intestines, note: no fever. WBC, slightly elevated. The Surgeon had penicillin administered. Now that leaves me with two possibilities. My immune system did not respond at all. Alternatively the Surgeon gambled that the penicillin would trip my immune system. It took two months to heal. He praised my wound care as better than Home Health. Realizing he gambled should worry me, yet I am more confident in him. The E.Coli. culture was actually a good thing. This brings me to an apology to ladyK, the bacterial balance appears to be urgent to my immune system. Considering the antibiotics left to me and coumadin, I better keep these little E.Coli buggers happy and very healthy. Talk about irony. 15951
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